The given directed acyclic graph represents the Bayesian Belief Network (BBN) which represents the conditional dependencies between the random variables.
Here, $Z$ depends on $V$ and $W$ and both $V$ and $W$ depends on $U.$
So the joint probability:
$\mathbb{P}(Z,V,W,U)=\mathbb{P}(Z|V \cap W)*\mathbb{P}(V \cap W)$ $(1)$
Now,
$V$ and $W$ are conditionally independent given $U.$
So,
$\mathbb{P}(V \cap W) = \mathbb{P}(V \cap W | U)\mathbb{P}(U)+\mathbb{P}(V \cap W | \neg U)\mathbb{P}(\neg U)$
Since, $V$ and $W$ are conditionally independent so $\mathbb{P}(V \cap W | U) =\mathbb{P}(V| U)*\mathbb{P}(W | U)$ and $\mathbb{P}(V \cap W | \neg U) =\mathbb{P}(V| \neg U)*\mathbb{P}(W | \neg U)$
Hence,
$\mathbb{P}(V \cap W) =\mathbb{P}(V| U)*\mathbb{P}(W | U) \mathbb{P}(U)+\mathbb{P}(V| \neg U)*\mathbb{P}(W | \neg U)\mathbb{P}(\neg U)$
So, from $(1)$
$\mathbb{P}(Z,V,W,U)=\mathbb{P}(Z|V \cap W)*[\mathbb{P}(V| U)*\mathbb{P}(W | U) \mathbb{P}(U)+\mathbb{P}(V| \neg U)*\mathbb{P}(W | \neg U)\mathbb{P}(\neg U)]$
Therefore,
$\mathbb{P}(Z=1,V=1,W=1,U=1)=\mathbb{P}(Z=1|V=1, W=1)*[\mathbb{P}(V=1| U=1)*\mathbb{P}(W=1 | U=1) \mathbb{P}(U=1)+$
$\mathbb{P}(V=1| U=0)*\mathbb{P}(W=1 | U=0)\mathbb{P}(U=0)]$
$\mathbb{P}(Z=1,V=1,W=1,U=1)=0.5[0.5*1*0.5+0.5*0]=0.125$